Estrogens esterified
Amnestrogen, Duavee, Estratab, Evex, Femogen, Menest, Menrium, Milprem, Pmb, Premarin, Premphase, Prempro (estrogens, esterified) is an unknown pharmaceutical. Estrogens, esterified was first approved as Menrium 5-2 on 1982-01-01.
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| covaryx | unapproved drug other | 2020-01-25 |
| covaryx covaryx | unapproved drug other | 2013-02-26 |
| duavee | New Drug Application | 2024-07-15 |
| eemt | unapproved drug other | 2020-01-22 |
| eemt eemt | unapproved drug other | 2013-03-01 |
| esterified estrogens and methyltestosterone | unapproved drug other | 2024-09-06 |
| esterified estrogens and methytestesterone | unapproved drug other | 2022-11-25 |
| estratest f.s. | unapproved drug other | 2024-09-06 |
| estratest f.s. estratest h.s. | unapproved drug other | 2024-06-15 |
| menest | ANDA | 2024-02-23 |
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Indications
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Agency Specific
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ATC Codes
G: Genito urinary system and sex hormones
— G03: Sex hormones and modulators of the genital system
— G03A: Hormonal contraceptives for systemic use
— G03AA: Progestogens and estrogen systemic contraceptives, fixed combinations
— G03AA14: Nomegestrol and estradiol
— G03AA17: Medroxyprogesterone and estradiol
— G03AB: Progestogens and estrogens systemic contraceptives, sequential preparations
— G03AB08: Dienogest and estradiol
— G03C: Estrogens, sex hormones and modulators of the genital system
— G03CA: Natural and semisynthetic estrogens, plain
— G03CA03: Estradiol
— G03CA53: Estradiol, combinations
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01C: Hypothalamic hormones
— H01CC: Anti-gonadotropin-releasing hormones
— H01CC53: Elagolix, estradiol and norethisterone
— H01CC54: Relugolix, estradiol and norethisterone
HCPCS
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Clinical
Clinical Trials
153 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Menopause | D008593 | EFO_0003922 | N95 | 6 | 8 | 4 | 7 | 2 | 27 |
| Postmenopause | D017698 | — | — | 8 | 5 | 3 | 2 | 3 | 21 |
| Atrophy | D001284 | — | — | 2 | — | 5 | 1 | 2 | 10 |
| Atrophic vaginitis | D059268 | EFO_1001271 | — | 2 | — | 3 | 3 | 1 | 9 |
| Hot flashes | D019584 | — | — | — | 1 | 4 | 2 | 2 | 9 |
| Vaginitis | D014627 | EFO_0005757 | N76 | 3 | — | 1 | 3 | 2 | 9 |
| Pelvic organ prolapse | D056887 | EFO_0004710 | — | — | — | 1 | 4 | 2 | 7 |
| Prolapse | D011391 | — | — | — | — | 1 | 4 | 2 | 7 |
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | — | — | — | 4 | 2 | 6 |
| Hyperplasia | D006965 | EFO_0000536 | — | — | 2 | 2 | 1 | — | 5 |
Show 27 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 2 | 15 | 10 | — | 2 | 28 |
| Adenocarcinoma | D000230 | — | — | 1 | 8 | 2 | — | — | 11 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 4 | 2 | — | 3 | 11 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | 1 | — | 6 | — | 2 | 9 |
| Carcinoma | D002277 | — | C80.0 | — | 5 | 1 | — | — | 6 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 2 | 5 | — | — | 6 |
| Neoplasms | D009369 | — | C80 | — | 3 | 1 | — | — | 4 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 2 | 3 | — | — | 4 |
| Coronary disease | D003327 | — | — | — | 1 | 4 | — | — | 4 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | 4 | — | — | 4 |
Show 11 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | 2 | — | — | — | 2 |
| Lymphatic metastasis | D008207 | EFO_1001364 | — | — | 1 | — | — | — | 1 |
| Risk reduction behavior | D040242 | — | — | — | 1 | — | — | — | 1 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | 1 | — | — | — | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 1 | — | — | — | 1 |
| Sclerosis | D012598 | — | — | — | 1 | — | — | — | 1 |
| Carcinoma in situ | D002278 | — | D09.9 | — | 1 | — | — | — | 1 |
| Breast carcinoma in situ | D000071960 | — | D05 | — | 1 | — | — | — | 1 |
| Ductal carcinoma breast | D018270 | — | — | — | 1 | — | — | — | 1 |
| Intraductal carcinoma noninfiltrating | D002285 | — | D05.1 | — | 1 | — | — | — | 1 |
Show 20 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | 2 | — | — | — | 1 | 3 |
| Estrogen replacement therapy | D015914 | — | — | 2 | — | — | — | — | 2 |
| Postmenopausal osteoporosis | D015663 | EFO_0003854 | — | 1 | — | — | — | 1 | 2 |
| Premature menopause | D008594 | HP_0008209 | E28.31 | 2 | — | — | — | — | 2 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 1 | — | — | — | — | 1 |
| Sleep | D012890 | GO_0030431 | — | 1 | — | — | — | — | 1 |
| Metrorrhagia | D008796 | HP_0100608 | N92.1 | 1 | — | — | — | — | 1 |
| Premature birth | D047928 | EFO_0003917 | O60 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 1 | 1 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | — | 1 | 1 |
| Gender dysphoria | D000068116 | — | — | — | — | — | — | 1 | 1 |
| Breast density | D000071060 | — | — | — | — | — | — | 1 | 1 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | — | — | 1 | 1 |
| Male breast neoplasms | D018567 | — | — | — | — | — | — | 1 | 1 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Estrogens esterified |
| INN | — |
| Description | 17beta-estradiol is the 17beta-isomer of estradiol. It has a role as an estrogen, a human metabolite, an EC 1.2.3.1 (aldehyde oxidase) inhibitor, a Daphnia magna metabolite, a mouse metabolite and a geroprotector. It is a 17beta-hydroxy steroid and an estradiol. |
| Classification | Unknown |
| Drug class | estrogens; steroids (androgens, anabolics) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 141290-02-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201468 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB09381 |
| UNII ID | — |
Target
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Variants
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Premarin – Pfizer
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Trends
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Additional graphs summarizing 1,966 documents
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Safety
Black-box Warning
Black-box warning for: Covaryx, Covaryx covaryx, Duavee, Eemt, Eemt eemt, Esterified estrogens and methyltestosterone, Esterified estrogens and methytestesterone, Estratest f.s., Estratest f.s. estratest h.s., Menest, Premarin, Premphase, Premphase prempro, Prempro
Adverse Events
Top Adverse Reactions
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59,693 adverse events reported
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