Estrogens esterified
Amnestrogen, Duavee, Estratab, Evex, Femogen, Menest, Menrium, Milprem, Pmb, Premarin, Premphase, Prempro (estrogens, esterified) is an unknown pharmaceutical. Estrogens, esterified was first approved as Menrium 5-2 on 1982-01-01.
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Commercial
Therapeutic Areas
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Trade Name
FDA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| covaryx | unapproved drug other | 2020-01-25 |
| covaryx covaryx | unapproved drug other | 2013-02-26 |
| duavee | New Drug Application | 2025-01-13 |
| eemt | unapproved drug other | 2020-01-22 |
| eemt eemt | unapproved drug other | 2013-03-01 |
| esterified estrogens and methyltestosterone | unapproved drug other | 2025-02-10 |
| esterified estrogens and methyltestosterone full strength esterified estrogens and methyltestosterone half strength | unapproved drug other | 2025-03-10 |
| esterified estrogens and methytestesterone | unapproved drug other | 2022-11-25 |
| estratest f.s. | unapproved drug other | 2024-09-06 |
| estratest f.s. estratest h.s. | unapproved drug other | 2024-06-15 |
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Indications
FDA
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Agency Specific
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ATC Codes
G: Genito urinary system and sex hormones
— G03: Sex hormones and modulators of the genital system
— G03A: Hormonal contraceptives for systemic use
— G03AA: Progestogens and estrogen systemic contraceptives, fixed combinations
— G03AA14: Nomegestrol and estradiol
— G03AA17: Medroxyprogesterone and estradiol
— G03AB: Progestogens and estrogens systemic contraceptives, sequential preparations
— G03AB08: Dienogest and estradiol
— G03C: Estrogens, sex hormones and modulators of the genital system
— G03CA: Natural and semisynthetic estrogens, plain
— G03CA03: Estradiol
— G03CA53: Estradiol, combinations
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01C: Hypothalamic hormones
— H01CC: Anti-gonadotropin-releasing hormones
— H01CC53: Elagolix, estradiol and norethisterone
— H01CC54: Relugolix, estradiol and norethisterone
HCPCS
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Clinical
Clinical Trials
1437 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leiomyoma | D007889 | — | D25 | — | 1 | 4 | — | 2 | 7 |
| Myofibroma | D047708 | — | — | — | 1 | 4 | — | 2 | 7 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | 1 | 4 | — | 1 | 6 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | 1 | 4 | — | 1 | 6 |
| Endometriosis | D004715 | EFO_0001065 | N80 | 1 | 1 | 2 | — | — | 4 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Uterine hemorrhage | D014592 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Infertility | D007246 | EFO_0000545 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Estrogens esterified |
| INN | — |
| Description | 17beta-estradiol is the 17beta-isomer of estradiol. It has a role as an estrogen, a human metabolite, an EC 1.2.3.1 (aldehyde oxidase) inhibitor, a Daphnia magna metabolite, a mouse metabolite and a geroprotector. It is a 17beta-hydroxy steroid and an estradiol. |
| Classification | Unknown |
| Drug class | estrogens; steroids (androgens, anabolics) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 141290-02-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201468 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB09381 |
| UNII ID | — |
Target
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Variants
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Financial
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Premarin – Pfizer
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Trends
PubMed Central
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Additional graphs summarizing 50,684 documents
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Safety
Black-box Warning
Black-box warning for: Covaryx, Covaryx covaryx, Duavee, Eemt, Eemt eemt, Esterified estrogens and methyltestosterone, Esterified estrogens and methyltestosterone full strength esterified estrogens and methyltestosterone half strength, Esterified estrogens and methytestesterone, Estratest f.s., Estratest f.s. estratest h.s., Estratest fs estratest hs, Menest, Premarin, Premphase, Premphase prempro, Prempro
Adverse Events
Top Adverse Reactions
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104,985 adverse events reported
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